2il9

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spinqualitylabelsall models 2il9, resolution 3.100Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms

Overview

Canonical cap-dependent translation initiation requires a large number of, protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some, cases completely supplant these factors by recruiting and activating the, ribosome using a single structured RNA. Here we present the crystal, structures of the ribosome-binding domain from a Dicistroviridae, intergenic region IRES at 3.1 angstrom resolution, providing a view of the, prefolded architecture of an all-RNA translation initiation apparatus., Docking of the structure into cryo-electron microscopy reconstructions of, an IRES-ribosome complex suggests a model for ribosome manipulation by a, dynamic IRES RNA.

About this Structure

2IL9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290

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