2isd

From Proteopedia

Revision as of 10:18, 21 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:2isd.jpg

2isd, resolution 2.5Å

Drag the structure with the mouse to rotate

PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT

Overview

Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act, as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of, phospholipase C delta 1 reveals a multidomain protein incorporating, modules shared by many signalling proteins. The structure suggests a, mechanism for membrane attachment and Ca2+-dependent hydrolysis of, second-messenger precursors. The regulation and reversible membrane, association of PI-PLC may serve as a model for understanding other, multidomain enzymes involved in phospholipid signalling.

About this Structure

2ISD is a Single protein structure of sequence from Rattus norvegicus with ACT as ligand. This structure superseeds the now removed PDB entry 1ISD. Active as Phosphoinositide phospholipase C, with EC number 3.1.4.11 Full crystallographic information is available from OCA.

Reference

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta., Essen LO, Perisic O, Cheung R, Katan M, Williams RL, Nature. 1996 Apr 18;380(6575):595-602. PMID:8602259

Page seeded by OCA on Wed Nov 21 12:26:02 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2isd"
Personal tools