4j8e

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Template:STRUCTURE 4j8e

Middle domain of Hsc70-interacting protein, crystal form I

Function

[F10A1_RAT] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.

About this Structure

4j8e is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

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