2nnz
From Proteopedia
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Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus
Overview
AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it, belongs to the PFam domain of unknown function 369 (DUF369). NMR, structural determination reveals that AF2241 adopts a cyclophilin-like, fold, with a beta-barrel core composed of eight beta-strands, one, alpha-helix, and one 3(10) helix located at each end of the barrel. The, protein displays a high structural similarity to TM1367, another member of, DUF369 whose structure has been determined recently by X-ray, crystallography. Structural similarity search shows that AF2241 also has a, high similarity to human cyclophilin A, however, sequence alignment and, electrostatic potential analysis reveal that the residues in the PPIase, catalytic site of human cyclophilin A are not conserved in AF2241 or, TM1367. Instead, a putative active site of AF2241 maps to a negatively, charged pocket composed of 9 conserved residues. Our results suggest that, although AF2241 adopts the same fold as the human cyclophilin A, it may, have distinct biological function.
About this Structure
2NNZ is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
Reference
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131
Page seeded by OCA on Wed Jan 23 13:52:15 2008
