3ink

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Template:STRUCTURE 3ink

Contents

UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY

Disease

[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Function

[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

About this Structure

3ink is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Bazan JF. Unraveling the structure of IL-2. Science. 1992 Jul 17;257(5068):410-3. PMID:1631562
  • Wang Y, Li L, Liu J, Wang Z, Jiang C, Liu X. The analgesic domain of IL-2. Biochem Biophys Res Commun. 1997 Jan 23;230(3):542-5. PMID:9015358 doi:10.1006/bbrc.1996.5961
  • Eckenberg R, Xu D, Moreau JL, Bossus M, Mazie JC, Tartar A, Liu XY, Alzari PM, Bertoglio J, Theze J. Analysis of human IL-2/IL-2 receptor beta chain interactions: monoclonal antibody H2-8 and new IL-2 mutants define the critical role of alpha helix-A of IL-2. Cytokine. 1997 Jul;9(7):488-98. PMID:9237811 doi:10.1006/cyto.1996.0192

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