2nsn

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spinqualitylabelsall models 2nsn, resolution 2.000Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of, pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain, protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich, repeat domain (LRR). The binding of PAMPs to the LRR results in the, activation of signaling through homophilic CARD-CARD interactions. Several, CARD structures have been determined, including a recent NMR structure of, Nod1 CARD. In contrast to the reported NMR structure, the crystal, structure reported here is a dimer, where the sixth helix is swapped, between two monomers. While the overall structure is very similar to the, known CARD structures, this is the first report of a homodimeric CARD, structure. The ability of the CARD to exist in monomeric and dimeric forms, suggests another level of regulation in the activation of NLR proteins.

Disease

Known disease associated with this structure: Hydatidiform mole OMIM:[609661]

About this Structure

2NSN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Nod1 caspase activation and recruitment domain., Coussens NP, Mowers JC, McDonald C, Nunez G, Ramaswamy S, Biochem Biophys Res Commun. 2007 Feb 2;353(1):1-5. Epub 2006 Dec 6. PMID:17173864

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