2oo4

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Image:2oo4.gif

2oo4, resolution 2.003Å

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Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

Overview

Notch receptors transmit signals between adjacent cells. Signaling is, initiated when ligand binding induces metalloprotease cleavage of Notch, within an extracellular negative regulatory region (NRR). We present here, the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited, conformation. Extensive interdomain interactions within the NRR bury the, metalloprotease site, showing that a substantial conformational movement, is necessary to expose this site during activation by ligand., Leukemia-associated mutations in NOTCH1 probably release autoinhibition by, destabilizing the conserved hydrophobic core of the NRR.

About this Structure

2OO4 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.

Reference

Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372

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