2oq1
From Proteopedia
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Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide
Contents |
Overview
The crystal structure of the tandem SH2 domains of human ZAP-70 in complex, with a peptide derived from the zeta-subunit of the T-cell receptor, reveals an unanticipated interaction between the two domains. A coiled, coil of alpha-helices connects the two SH2 domains, producing an interface, that constitutes one of the two critical phosphotyrosine binding sites., These and other unique features provide the molecular basis for highly, selective association of ZAP-70 with the T-cell receptor.
Disease
Known diseases associated with this structure: Immunodeficiency due to defect in CD3-zeta OMIM:[186780], Selective T-cell defect OMIM:[176947]
About this Structure
2OQ1 is a Protein complex structure of sequences from Homo sapiens with PB as ligand. Active as Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor., Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, et al., Nature. 1995 Sep 7;377(6544):32-8. PMID:7659156
Page seeded by OCA on Mon Nov 12 23:14:52 2007
