2oyp
From Proteopedia
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T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface
Overview
The T cell immunoglobulin mucin (Tim) family of receptors regulates, effector CD4(+) T cell functions and is implicated in autoimmune and, allergic diseases. Tim-3 induces immunological tolerance, and engagement, of the Tim-3 immunoglobulin variable (IgV) domain by galectin-9 is, important for appropriate termination of T helper 1-immune responses. The, 2 A crystal structure of the Tim-3 IgV domain demonstrated that four, cysteines, which are invariant within the Tim family, form two, noncanonical disulfide bonds, resulting in a surface not present in other, immunoglobulin superfamily members. Biochemical and biophysical studies, demonstrated that this unique structural feature mediates a previously, unidentified galectin-9-independent binding process and suggested that, this structural feature is conserved within the entire Tim family. The, current work provided a graphic example of the relationship between, sequence, structure, and function and suggested that the interplay between, multiple Tim-3-binding activities contributes to the regulated assembly of, signaling complexes required for effective Th1-mediated immunity.
About this Structure
2OYP is a Single protein structure of sequence from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface., Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC, Immunity. 2007 Mar;26(3):311-21. PMID:17363302
Page seeded by OCA on Tue Jan 29 21:17:43 2008
