4kpb

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Template:STRUCTURE 4kpb

Contents

Crystal structure of cytochrome P450 BM-3 R47E mutant

Template:ABSTRACT PUBMED 23829560

Function

[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.

About this Structure

4kpb is a 2 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

  • Catalano J, Sadre-Bazzaz K, Amodeo GA, Tong L, McDermott AE. Structural Evidence: A Single Charged Residue Affects Substrate Binding in Cytochrome P450 BM-3. Biochemistry. 2013 Jul 6. PMID:23829560 doi:10.1021/bi4000645

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OCA

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