Sandbox Reserved 783

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This Sandbox is Reserved from Oct 10, 2013, through May 20, 2014 for use in the course "CHEM 410 Biochemistry 1 and 2" taught by Hanna Tims at the Messiah College. This reservation includes Sandbox Reserved 780 through Sandbox Reserved 807.

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spinqualitylabelsall models Fumarase Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

is a vital part of the citric acid cycle. It aids in the interconversion of malate to fumarate and overall in the production of NADH. Genetic mutations of fumarase has often been associated with the development of leiofibromyomas in the skin and uterus in combination with renal cell carcinoma. Studies have been conducted to explore the possible connections present with a heritable cancer predispositions for young females with a history of uterine fibroids, related to Reed Syndrome. Other studies have observed the overall effect of rats fed high fat diets and the resulting effects of fumarase.

Fumarase

This image depicts the of fumarase(1FUO). Alpha helices are represented in coral color, and beta sheets are yellow. Alpha helices make up most of the structure of fumarase. There are also random chains colored blue and green within this depiction of its secondary structure. The ligand is represented by red and gray molecules at the end of the alpha helices. The of fumarase allow for the coiled coil of the alpha helices to exist.

Some of the portions of fumarase (gray) and portions (red) illustrate the complex interactions between residues. It can also be observed that many hydrophobic portions are present within the tertiary structure of coiled coils. is shown through the blue spheres representing water molecules (the solvent) and the ribbon structure of fumarase (white). The ligand is represented in orange. As can be seen, the center of the coiled coil is inaccessible to solvent, as is center of the protein, where the catalytic residues are present. The (wire and stick representation) present during reaction is Malate ion. As can be seen in the model, the side chains that interact with the ligand possess a positive charge, creating covalent bonds with the malate ion which contains several carbonyl carbons.

In fumarase, are illustrated in a green, wire and stick representation. are represented in purple wire and stick representations.