Sandbox Reserved 780

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This Sandbox is Reserved from Oct 10, 2013, through May 20, 2014 for use in the course "CHEM 410 Biochemistry 1 and 2" taught by Hanna Tims at the Messiah College. This reservation includes Sandbox Reserved 780 through Sandbox Reserved 807.

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spinqualitylabelsall models Fumarase Dimer Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This is . Fumarase is an enzyme of the citric acid cycle or Kreb's cycle. The function of fumarase is to stereospecifically convert fumarate into L-malate. This specific image (1FUO) is of Fumarase C from E. Coli. It is a dimer bound with 2 ligands; 2 citrate molecules and 2 malate molecules. The two citrate molecules are the two center and the malate molecules are the outer two ligands shown. The fumarate/L-malate conversion is reversible.

A moajority of fumarase's secondary structure is composed of shown in blue. The longer α-helicies are grouped together and appear to form short coiled coils which compse the mid section of the enzyme's structure. Fumarase contains 3 small sections of , each consisting of two strands in anti-parallel allignment connected by a short random coil.