Sandbox Reserved 784

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This Sandbox is Reserved from Oct 10, 2013, through May 20, 2014 for use in the course "CHEM 410 Biochemistry 1 and 2" taught by Hanna Tims at the Messiah College. This reservation includes Sandbox Reserved 780 through Sandbox Reserved 807.

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spinqualitylabelsall models pyruvate kinase Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Introduction

Pyruvate kinase (a transferase, PDB 4IP7) What's it do Research about it

Structure

Pyruvate kinase is a , meaning it has four identical . This enzyme contains both and .

It has three . consists of an alpha-beta-alpha 3-layer sandwich. consists of a parallel alpha-beta barrel. consists of an anti-parallel beta-barrel.

in the backbone show the interactions within the elements of secondary structure.

Solvent When you look at , you see that water surrounds everywhere except the

The ligands, substrate, cofactors, etc What kinds of side chains?

Ligand contacts

Catalytic residues

in green