4kp7
From Proteopedia
Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin
Template:ABSTRACT PUBMED 24032981
About this Structure
4kp7 is a 2 chain structure with sequence from Plasmodium falciparum hb3. Full crystallographic information is available from OCA.
Reference
- Kunfermann A, Lienau C, Illarionov B, Held J, Grawert T, Behrendt CT, Werner P, Hahn S, Eisenreich W, Riederer U, Mordmuller B, Bacher A, Fischer M, Groll M, Kurz T. IspC as target for antiinfective drug discovery: Synthesis, enantiomeric separation and structural biology of fosmidomycin thia-isosters. J Med Chem. 2013 Sep 13. PMID:24032981 doi:10.1021/jm4012559
Categories: 1-deoxy-D-xylulose-5-phosphate reductoisomerase | Plasmodium falciparum hb3 | Bacher, A. | Groll, M. | Kunfermann, A. | Apicoplast | Drug optimization | Dxp pathway | Malaria | Nadph binding | Non-covalent inhibition | Oxidoreductase-oxidoreductase inhibitor complex | Reductoisomerase | Rossmann fold | Tuberculosis
