4kcc

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4kcc

Contents 1 Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State 2 Function 3 About this Structure 4 Reference

Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State

Function

[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.^[1]

About this Structure

4kcc is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

1. ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022