4i2h

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Template:STRUCTURE 4i2h

Contents

Ternary complex of mouse TdT with ssDNA and AMPcPP

Template:ABSTRACT PUBMED 23856622

Function

[TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

About this Structure

4i2h is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Gouge J, Rosario S, Romain F, Beguin P, Delarue M. Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J Mol Biol. 2013 Jul 13. pii: S0022-2836(13)00441-5. doi:, 10.1016/j.jmb.2013.07.009. PMID:23856622 doi:10.1016/j.jmb.2013.07.009

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