4bmj

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Template:STRUCTURE 4bmj

Contents 1 Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1 2 Function 3 About this Structure 4 Reference

Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1

Function

[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.^{[1] [2]}

About this Structure

4bmj is a 11 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:http://dx.doi.org/10.1038/sj.onc.1202787
2. ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:http://dx.doi.org/10.1073/pnas.170279097