4c9r
From Proteopedia
Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I
Function
[ZNRF3_XENTR] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). [RSPO2_XENTR] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
About this Structure
4c9r is a 4 chain structure. Full crystallographic information is available from OCA.
Categories: Jones, E Y. | Zebisch, M. | Lgr4 | Lgr5 | Lgr6 | Ligase-signaling protein complex | Membrane | R-spo | R-spondin | Receptor | Rnf43 | Rspo | Rspo1 | Rspo3 | Rspo4 | Signalling | Wnt
