4ld0

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Template:STRUCTURE 4ld0

Contents

T. thermophilus RuvC in complex with Holliday junction substrate

Template:ABSTRACT PUBMED 23980027

Function

[RUVC_THET8] Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity).

About this Structure

4ld0 is a 5 chain structure with sequence from Thermus thermophilus hb8. Full crystallographic information is available from OCA.

Reference

  • Gorecka KM, Komorowska W, Nowotny M. Crystal structure of RuvC resolvase in complex with Holliday junction substrate. Nucleic Acids Res. 2013 Sep 18. PMID:23980027 doi:10.1093/nar/gkt769

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OCA

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