2r18
From Proteopedia
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Structural insights into the multifunctional protein VP3 of Birnaviruses
Overview
Infectious bursal disease virus (IBDV), a member of the Birnaviridae, family, is the causative agent of one of the most harmful poultry, diseases. The IBDV genome encodes five mature proteins; of these, the, multifunctional protein VP3 plays an essential role in virus, morphogenesis. This protein, which interacts with the structural protein, VP2, with the double-stranded RNA genome, and with the virus-encoded, RNA-dependent RNA polymerase, VP1, is involved not only in the formation, of the viral capsid, but also in the recruitment of VP1 into the capsid, and in the encapsidation of the viral genome. Here, we report the X-ray, structure of the central region of VP3, residues 92-220, consisting of two, alpha-helical domains connected by a long and flexible hinge that are, organized as a dimer. Unexpectedly, the overall fold of the second VP3, domain shows significant structural similarities with different, transcription regulation factors.
About this Structure
2R18 is a Single protein structure of sequence from Infectious bursal disease virus. Full crystallographic information is available from OCA.
Reference
Structural insights into the multifunctional protein VP3 of birnaviruses., Casanas A, Navarro A, Ferrer-Orta C, Gonzalez D, Rodriguez JF, Verdaguer N, Structure. 2008 Jan;16(1):29-37. PMID:18184581
Page seeded by OCA on Wed Feb 13 08:14:33 2008
