2r2w

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Image:2r2w.jpg

2r2w, resolution 2.01Å

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Urokinase plasminogen activator B-chain-GPPE complex

Overview

Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two, different environments was determined in order to compare the binding, geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a, target for anti-cancer drugs. It was shown that the conformation and the, hydrogen-bonding formation by GPPE molecule are similar in both, environments, but several important differences were discovered and, described.

About this Structure

2R2W is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as U-plasminogen activator, with EC number 3.4.21.73 Full crystallographic information is available from OCA.

Reference

Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator., Zeslawska E, Sturzebecher J, Oleksyn BJ, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6212-5. Epub 2007 Sep 8. PMID:17905583

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