Huan He/Sandbox1
From Proteopedia
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Interleukin-1 beta(IL-1β)
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IL-1β along with IL-1α is one of cytokines secreted from local inflammatory cells, are belong to IL-1 family. while the former is dominate and they have been distinguished by the cell with which they interact. IL-1β precursor need to be activated by protease (convertase or IL-1β converting enzyme) to form IL-1 active species. The active mature IL-1 mediates several components of the acute phase reaction, including the febrile response, secretion of adrenocorticotropic hormone (ACIH), and the synthesis of acute phase proteins. interleukin 1(IL-1) cytokines could mediate innate and adaptive immunity[1].
HUMAN INTERLEUKIN-1 BETA
THREE-DIMENSIONAL STRUCTURE OF IL-1β The molecule resembles a conical barrel with a shallow open face on one end and a closed face on the other. Themolecule contains 12 antiparallel 13-strands, where six of these (131, 14, 15, 18, 19, and 1312) constitute an antiparallel 1 barrel. The overall structure of the molecule consists of three similar fragments (Fl, F2, F3), each containing two pairs of 1 strands. Three pairs of 1 strands (one pair from each of the fragments) form the six stranded barrel; the other three pairs cover one end of the barrel, referred to as the "closed end." The amino and carboxy termini are close to each other at the "open end" of the barrel. The molecule has internal pseudo threefold symmetry, with each subunit (Fl, F2, F3) having a 13L13 motif. There are five 1-hairpins in this molecule, two of them in the open end and three at the closed end. The polypeptide a-carbon backbone of IL13, viewed perpendicular to the barrel axis, is shown in Fig. 1. 24 hydrophobic side chains line the inner surface of the barrel and both the ends of the barrel have concentrations of exposed polar residues.
TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA
STRUCTURE OF THE INTERLEUKIN-1BETA SIGNALING COMPLEX
