User:Alisha, Deepa, Pamiz/Sandbox 1

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Introduction

2D Structure & Biochemical Parameters of Esomeprazole Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole.
2D Structure & Biochemical Parameters of Esomeprazole Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole.
Esomeprazole is the (S) enantiomer of Omeprazole. Esomperazole is a Proton Pump Inhibitor (PPI) that binds to H+/K+-ATPase and inhibits the secretion of gastric acid from parietal cells into the lumen of the stomach. Esomeprazole’s commercial brand name, Nexium, is used to treat Gastro-esophageal Reflux Disease (GERD), peptic and gastric ulcers, and Zollinger-Ellison syndrome.[1]

Ulcers caused by the bacterium Helicobacter pylori can be treated using Esomeprazole in conjunction with proper antibiotics.[1] Gastric acid is released through the H+/K+-ATPase pump, which is the final step in acid release. [2] Esomeprazole is a specific, irreversible inhibitor of the pump. [2]

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Deepa Patel

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