4ie2
From Proteopedia
Crystal structure of human Arginase-2 complexed with inhibitor 1h
Template:ABSTRACT PUBMED 23453840
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4ie2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Arginase | Homo sapiens | Andreoli, M. | Beckett ,P. | Cousido-Siah, A. | Golebiowski, A. | Jagdmann, E. | Ji, M K. | Mazur, A. | Mitschler, A. | Padmanilayam, M. | Podjarny, A. | Ruiz, F X. | Ryder, T. | Schroeter, H. | Whitehouse, D. | Zandt, M C.Van. | Alpha/beta fold | Arginine metabolism | Hydrolase | Hydrolase-hydrolase inhibitor complex | Manganese | Metalloenzyme | Mitochondrion
