4h24

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Template:STRUCTURE 4h24

Contents

Cytochrome P411BM3-CIS cyclopropanation catalyst

Template:ABSTRACT PUBMED 23792734

Function

[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.

About this Structure

4h24 is a 4 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

  • Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nat Chem Biol. 2013 Jun 23. doi: 10.1038/nchembio.1278. PMID:23792734 doi:10.1038/nchembio.1278

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OCA

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