2uw0

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Image:2uw0.gif

2uw0, resolution 2.00Å

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STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE

Overview

6-phenylpurines were identified as novel, ATP-competitive inhibitors of, protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly, progressed to potent compounds using iterative protein-ligand, crystallography with a PKA-PKB chimeric protein. An elaborated lead, compound showed cell growth inhibition and effects on cellular signaling, pathways characteristic of PKB inhibition.

About this Structure

2UW0 is a Protein complex structure of sequences from Bos taurus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design., Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I, J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235

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