4k44

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Template:STRUCTURE 4k44

Contents

Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes

Template:ABSTRACT PUBMED 23777354

Function

[PLCG1_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).

About this Structure

4k44 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek JE. Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes. Biochemistry. 2013 Jun 18. PMID:23777354 doi:10.1021/bi400433b

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