3b5n

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spinqualitylabelsall models 3b5n, resolution 1.600Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structure of the yeast plasma membrane SNARE complex

Overview

SNARE proteins form a complex that leads to membrane fusion between, vesicles, organelles, and plasma membrane in all eukaryotic cells. We, report the 1.7 A resolution structure of the SNARE complex that mediates, exocytosis at the plasma membrane in the yeast S. cerevisiae. Similar to, its neuronal and endosomal homologues, the S. cerevisiae SNARE complex, forms a parallel four helix bundle in the center of which is an ionic, layer. The S. cerevisiae SNARE complex exhibits increased helix bending, near the ionic layer, contains water filled cavities in the complex core, and exhibits reduced thermal stability relative to mammalian SNARE, complexes. Mutagenesis experiments suggest that the water-filled cavities, contribute to the lower stability of the S. cerevisiae complex.

About this Structure

3B5N is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of the yeast plasma membrane SNARE complex reveals destabilizing water filled cavities., Strop P, Kaiser SE, Vrljic M, Brunger AT, J Biol Chem. 2007 Oct 22;. PMID:17956869

Page seeded by OCA on Wed Jan 23 10:47:14 2008