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2yt2

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Template:STRUCTURE 2yt2

Contents

Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK

Template:ABSTRACT PUBMED 20454865

Function

[FRS3_HUMAN] Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.[1]

About this Structure

2yt2 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Koshiba S, Li H, Motoda Y, Tomizawa T, Kasai T, Tochio N, Yabuki T, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yamamoto T, Yokoyama S. Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2. J Struct Funct Genomics. 2010 May 8. PMID:20454865 doi:10.1007/s10969-010-9091-x
  1. ↑ Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett. 2004 Apr 23;564(1-2):14-8. PMID:15094036 doi:10.1016/S0014-5793(04)00287-X

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OCA

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