Chromodomain-helicase-DNA-binding protein
From Proteopedia
Chromodomain-helicase-DNA-binding proteins (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower. CHDs contain several domains such as chromodomain which is found in proteins involved in chromatin remodeling, PHD zinc finger which has Cys4-His-Cys3 motif and BRK domain which is associated with chromodomains.
- CHD1 - ATP-dependent chromatin-modeling factor. Functions as substrate recognition component of the transcription regulatory acetylation complex SAGA.
- CHD4 - Chromatin-modeling factor. Functions as component of the transcription regulatory deacetylation complex NuRD.
- CHD6 - Probable transcription regulator.
- CHD7 - ATP-dependent chromatin-modeling factor. May be involved in the 45S precursor ribosomal RNA production.
- CHD8 - acts as transcription repressor by modeling chromatin structure and recruiting histone H1 to target genes.
3D structures of CHD
Updated on 05-December-2013
2b2t – hCHD1 (mutant) + histone H3 tail – human
2b2u, 2b2v, 2b2w - hCHD1 + histone H3 tail
2b2y - hCHD1
2l5u – hCHD4 PHD finger 1 – NMR
2l75 - hCHD4 PHD finger 2 + histone H3 peptide – NMR
2ee1 – hCHD4 chromodomain – NMR
2epb – hCHD6 chromodomain 2 – NMR
2ckc, 2v0e, 2v0f – hCHD7 BRK domain - NMR
2dl6, 2cka – hCHD8 BRK domain - NMR
