4hmn
From Proteopedia
Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)
Function
[AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
About this Structure
4hmn is a 1 chain structure. Full crystallographic information is available from OCA.
Categories: Atwell, G J. | Brooke, D G. | Denny, W A. | Flanagan, J U. | Heinrich, D M. | Jamieson, S M.F. | Owen, P J. | Raynham, T. | Rigoreau, L J.M. | Samlal, S S. | Schroeder, E. | Silva, S. | Soudy, C. | Trivier, E. | Turnbull, A P. | Aldo-keto reductase | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Tim-barrel
