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Glucose 6 Phophate Dehydrogenease is an enzyme that plays a key role in the pentose phosphate pathway [1]
==Glucose-6-Phosphate Dehydrogenase Deficiency
Classification
The World Health Organization classifies G6PD genetic variants into five classes, the first three of which are deficiency states.[2]
- Severe deficiency (<10% activity) with chronic (nonspherocytic) hemolytic anemia
- Severe deficiency (<10% activity), with intermittent hemolysis
- Mild deficiency (10-60% activity), hemolysis with stressors only
- Non-deficient variant, no clinical sequelae
- Increased enzyme activity, no clinical sequelae
