Proteinase
From Proteopedia
Proteinase (PRO) are enzymes which hydrolyze peptide bonds. They are classified by the amino acid site of their cleavage or by the pH at which they are active. PRO B is a serine protease. For more details on PRO B see Streptomyces griseus proteinase B. PRO A is a carboxylproteinase. PRO K is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO K is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO K is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin). 3D structures of proteinaseUpdated on 16-April-2014 PRO A 2sga – SgPRO – Streptomyces griseus 2jxr, 1fmu, 1fmx – yPRO - yeast PRO B 3sgb – SgPRO + turkey ovomucoid inhibitor 1sgp, 1sgq, 1sgr, 1cso, 1ct0, 1ct2, 1ct4, 1ds2, 2sgp, 2nu3, 2nu4 – SgPRO + turkey ovomucoid inhibitor (mutant) PRO K 2prk, 1cnm, 1egq, 2id8, 2g4v, 2v8b, 3gt3, 3gt4, 3d9q, 3ddz, 3de0 , 3de1, 3de2, 3de3, 3de4, 3de5, 3de6, 3de7, 3dvq, 3dvr, 3dvs, 3dw1, 3dw3, 3dwe, 3i2y, 3i30, 3i37, 3i34, 3l1k, 3aj8, 3aj9, 3q40, 3q5g, 3qmp, 4b5l, 4fon – EaPRO + Ca – Engyodontium album 1ic6 – EaPRO (mutant) + Ca PRO K complex with peptide 3prk, 1p7v, 1p7w – EaPRO + Ca + peptide inhibitor 1bjr, 2dqk, 2duj – EaPRO + Ca + lactoferrin peptide PRO K complex with small molecule 2pwb – EaPRO + Ca + coumarin 2pyz – EaPRO + Ca + auramine PRO 3C 1qa7 – PRO – Hepatitis virus 2vb0 - PRO – Coxsakievirus H2-PRO 1wni – PRO – Trimeresurus flavoviridis Aspartic PRO 2asi – PRO – Rhizomucor miehei 1zap – CaPRO – Candida albicans Cysteine PRO 2hrv – PRO 2A – human rhinovirus Serine PRO 3s9a, 3s9b – RvPRO – Siamese Russell’s viper
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References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Karsten Theis
