1f6k

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Template:STRUCTURE 1f6k

Contents

CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM II

Template:ABSTRACT PUBMED 11031117

Function

[NANA_HAEIN] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.

About this Structure

1f6k is a 2 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

  • Barbosa JA, Smith BJ, DeGori R, Ooi HC, Marcuccio SM, Campi EM, Jackson WR, Brossmer R, Sommer M, Lawrence MC. Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme. J Mol Biol. 2000 Oct 27;303(3):405-21. PMID:11031117 doi:http://dx.doi.org/10.1006/jmbi.2000.4138

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