2atb
From Proteopedia
Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT
Function
[SCXA_LEIQH] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.
About this Structure
2atb is a 2 chain structure with sequence from Leiurus quinquestriatus. Full crystallographic information is available from OCA.
Categories: Leiurus quinquestriatus | Frolow, F. | Gurevitz, M. | Kahn, R. | Karbat, I. | Alpha toxin | Muation | Scorpion | Toxin
