Ribosomal protein L7/L12

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Template:STRUCTURE 1dd3

Ribosomal protein L7 (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the L7/L12 complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7. In the archaea, the L7Ae acts as a subunit of RNase P.

3D Structures of Ribosomal protein L7

Updated on 15-October-2013

RPL7

1rqu, 1rqv - EcRPL7 - Escherichia coli - NMR
1dd3, 1dd4 - TmRPL7/L12 - Thermotoga maritima
1rqs – EcRPL7/L12 - NMR
1rqt - EcRPL7/L12 N-terminal – NMR
1ctf - EcRPL7/L12 C-terminal
3paf - MjRPL7Ae (mutant)
1ra4, 1xbi – MjRPL7Ae – Methasnocaldococcus jannaschii
1sds – MjRPL7Ae+box H/ACA RNA
2fc3 – RPL7Ae – Aeropyrum pernix
2czw – RPL7Ae – Pyrococcus horikoshii
1pxw - RPL7Ae – Pyrococcus abyssi
1rlg – RPL7Ae+RNA fragment – Archaeoglobus fulgidus
3pla - RPL7Ae + pre mRNA splicing protein + fibrillarin-like methyltransferase + RNA - Sulfolobus solfataricus
3o85 - RPL7Ae – Giardia lamblia
3nvi – PfRPL7Ae + NOP5/NOP56 + RNA – Pyrococcus furiosus
3nvk – PfRPL7Ae + NOP5/NOP56 + fibrillarin-like methyltransferase + RNA

L7 in 50S subunit+RNA

2j01, 2j03, 1yl3, 3i8i, 1giy, 4kbu, 4kbw, 4kcz, 4kd2, 4kd9, 4kdb, 4kdh, 4kdk - TtRPL7 in 50S subunit+5S RRNA+23S RRNA
2gya, 2gyc, 4kix - EcRPL7 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM
3uos, 3sgf - EcRPL7 in 50S subunit+5S RRNA+23S RRNA
2zjq, 2zjr - DrRPL7 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans
1kqs, 2qa4, 1qvg - HmRPL7 in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui
1jj2, 1ffk, 3cc2, 1s72 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA
1vqm, 1vql, 1vq7, 1vq4, 1vq5, 1vqp - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+transition state analogue
3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA (mutant)
1yj9 - HmRPL7Ae in 50S subunit (mutant)+5S RRNA+23S RRNA
3cma, 3cme - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCA+CCA-Phe-CAP-BIO
1vq6, 1vqn - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+C-hpmn+CCA-Phe-CAP-BIO
1vqk, 1q86 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCDA-Phe-CAP-BIO
1vqo - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCPMN
1qvf - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+deacylated tRNA minihelix

L7 in 50S subunit + antibiotics

3cxc – RPL7Ae in 50S subunit+5S RRNA+23S RRNA +oxazolidinone inhibitor – Halobacterium marismortui
1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 3qex, 3cpw, 3cc4, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+antibiotic
1m90 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
3cd6, 1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic
1vq8, 1vq9 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCDA-Phe-CAP-BIO+sparsomycin

L7 in 60S subunit

3jyw - RPL7 in 60S subunit – Thermomyces lanuginosus – Cryo-EM
3izr – RPL7 in 60S subunit – wheat – Cryo-EM
3j39 – RPL7 in 60S subunit – Drosophila melanogaster – Cryo-EM
3j3b – RPL7 in 60S subunit – human – Cryo-EM
3o58, 3o5h – yRPL7 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA
3izs – yRPL7 in 60S ribosomal subunit – yeast - Cryo-EM
3u5e, 3u5i – yRPL7 in 60S ribosomal subunit
4b6a - yRPL7 in 60S ribosomal subunit + P0 + P1 +P2 + ARX1 - Cryo-EM

L7 in large + small ribosomal subunit

2zkr - RPL7 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM – dog

L7 in 50S subunit + various proteins

1w2b - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
3lwo, 3lwp, 3lwq, 3lwr, 3lwv, 3hax, 3hay, 3hjw – PfRPL7Ae+pseudouridine synthase+ribosome biogenesis protein NOP10+H/ACA RNA+RNA fragment
2hvy - PfRPL7Ae+pseudouridine synthase+ribosome biogenesis protein NOP10+H/ACA RNA+small nucleolar RNP
3nmu - PfRPL7Ae + NOP5 related protein + RNA + fibrillarin-like methyltransferase
3id5 – SsRPL7Ae+pre RNA splicing protein+fibrillarin+half C/D RNA – Sulfolobus solfataricus

L7 in part of 50S subunit

2bcw – EcRPL7/L12+EcRPL11+EF-G
1zav, 1zaw, 1zax - TmRPL7/L12 N-terminal +RPL10