Ribosomal protein S15

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Template:STRUCTURE 1a32

Ribosomal protein S15 (RPS15) is one of the 22 proteins which belong to the of the bacterial ribosome. It is involved in the early steps of ribosome assembly. The images at the left and at the right correspond to one representative RPS15, i.e. the crystal structure of Ribosomal protein S15 from Thermus thermophilus (2zm6, chain O).

3D Structures of Ribosomal protein S15

Updated on 20-October-2013

S15

1a32 – RPS15 – Geobacillus stearothermophilus
1ab3, 2fkx - TtRPS15 – Thermus thermophilus - NMR
1kuq, 1f7y, 1dk1 - TtRPS15+16S RRNA fragment
2vaz – EcRPS15+RPSO mRNA operator – Escherichia coli – Cryo-EM
3ulw, 4iyl – RPS15 – Campylobacter jejuni
4a5u – EcRPS15 + RNA replicase polyprotein

S15 in small ribosomal subunit

2zm6, 1n36, 1j5e, 3oto- TtRPS15 in 30S ribosomal subunit+THX+16S RRNA
2vqe, 2vqf, 2uuc, 2e5l, 2uu9, 2uua, 2uub, 3pyn, 3pyq, 3pys, 3pyu - TtRPS15 in 30S ribosomal subunit+16S RRNA+RNA fragment
3i8g, 3i8h - TtRPS15 in 30S ribosomal subunit+16S RRNA+mRNA+tRNA-Phe
3kc4 – EcRPS15 in 30S ribosomal subunit
3i1m, 3i1o, 3df1, 3df3, 2vho, 2vhp, 2avy, 2aw7, 1pnx, 3ofo, 3ofp, 3or9, 3ora, 3kc4 - EcRPS15 in 30S ribosomal subunit+16S RRNA
1i94, 1fka, 3uxs, 3uxt, 4dr1 - TtRPS15 in 30S ribosomal subunit+16S RRNA
4duy, 4duz, 4dv0, 4dv1, 4dv2, 4dv3, 4dv4, 4dv5, 4dv6, 4dv7 - TtRPS15 in 30S ribosomal subunit+16S RRNA (mutant)
4dr4, 4b3m, 4b3r, 4b3s, 4b3t – TtRPS15 in 30S ribosomal subunit+16S RRNA + mRNA
1p87, 1p6g - EcRPS15 in 30S ribosomal subunit+16S RRNA – Cryo-EM
3bbn - RPS15 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach
2zkq – RPS15 in 40S ribosomal subunit+18S RRNA - dog

S15 in small + large ribosomal subunit

1ml5, 1eg0 - EcRPS15 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM
3j0l, 3j0o, 3j0p, 3j0q - RPS15 in 30S ribosomal subunit+50S ribosomal subunit+ RRNA fragments +mRNA fragment+ tRNA – rabbit - Cryo EM

S15 in small ribosomal subunit+ chain release factor (RF)

3mr8, 3ms0 – TtRPS15 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA
3d5a, 3d5c, 3f1e, 3f1g - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA
3zvo – TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3
2b64 - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1
2b9m - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2
2x9r, 2x9t, 2wh1, 2wh3 - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA
3f1e, 3f1g - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA
3uoq - EcRPS15 + 16S RRNA + mRNA + peptide chain release factor
4kfh, 4kfk - TtRPS15 in 30S ribosomal subunit+16S RRNA+ RF-2 + mRNA+ P-site tRNA fMet

S15 in small ribosomal subunit+tRNA+mRNA

2hgi - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet
4l6k, 4l6m - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA
2hgp - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
3t1h, 3t1y - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Lys +mRNA
3tvf, 3tvg, 3uyd, 3uyf - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA
3zn7, 3znd - TtRPS15 in 30S ribosomal subunit+16S RRNA+A-site tRNA Ile agmatidine + E-site tRNA Ile agmatidine + mRNA
3uz6, 3uz7, 3uzg, 3uzi - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA
2i2p, 2i2u - EcRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
2hgr, 3v6u, 3v6v, 4ej9, 4eja - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA
1yl4 – TtRPS15 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator
1pns - EcRPS15 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA
3j0u, 3j0v, 3j0x, 3j0z, 3j10, 3j20 – EcRPS15 in 30S ribosomal subunit+ A-site tRNA + P-site tRNA +16S RRNA+mRNA – Cryo-EM
3j13 – EcRPS15 in 30S ribosomal subunit+ P-site tRNA +16S RRNA+mRNA – Cryo-EM
1xnq, 1xnr - TtRPS15 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA
4gkj, 4gkk - TtRPS15 in 30S ribosomal subunit +16S RRNA +THX + mRNA + tRNA Met
4jv5, 4jya, 4k0k, 4k0l - TtRPS15 in 30S ribosomal subunit +16S RRNA +THX + mRNA + ASL-tRNA

S15 in small ribosomal subunit+A-site tRNA

2uxd, 2uxc - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA
1n32, 1n33 - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA
1n34 - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA
1xmo, 1xmq - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA
2uxb - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA

S15 in small ribosomal subunit+P-site tRNA

3i8g - TtRPS15 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA
3i8h, 3i9b, 3i9d - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA
1ibk - TtRPS15 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA
2wwl - EcRPS15 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - Escherichia coli
3i1q - EcRPS15 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA
3i1s, 3i1z, 3i21 - EcRPS15 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA

S15 in small ribosomal subunit+A-site tRNA+P-site tRNA

1ibl, 1ibm - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA

S15 in small ribosomal subunit+P-site tRNA+E-site tRNA

2ow8 - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA
2b9o - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA
2qnh - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA

S15 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA

2gy9, 2gyb - EcRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM
1jgo, 1jgp, 1jgq, 1gix - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA
4k0p - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA +mRNA +16S RRNA
3e1a, 3e1c - EcRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA

S15 in small ribosomal subunit + antibiotics

1i95, 1i97, 2hhh, 2f4v, 3oge, 3ogy, 3ohc, 3ohd, 3ohy, 3oi0, 3oi2, 3oi4, 4dr2, 4dr3 - TtRPS15 in 30S ribosomal subunit+16S RRNA+antibiotic
1hnw, 1hnx, 1hnz, 1fjg, 4aqy, 4dr5, 4dr6, 4dr7, 4khp - TtRPS15 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic
2qbb, 2qb9, 1vs5, 1vs7, 2qan, 2qal, 2qou, 2qow, 2qoy, 2qp0, 2z4k, 2z4m, 3oaq, 3oar, 3ofa, 3ofb, 3ofo, 3ofp, 3ofx, 3ofy - EcRPS15 in 30S ribosomal subunit+16S RRNA+antibiotic
3sfs – EcRPS15 in 30S ribosomal subunit+16S RRNA+ mRNA + RF-3 + antibiotic
4gaq, 4gas – EcRPS15 in 30S ribosomal subunit+16S RRNA+ mRNA + antibiotic
2j00, 2j02 - TtRPS15 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA
2wdg, 2wdh, 2wdk, 2wdm - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin
3knj, 3knh, 3knl, 3knn - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+ antibiotics
3uz3, 3uz4 - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA + paromomycin
4g5k, 4g5m, 4g5t, 4g5v - TtRPS15 in 30S ribosomal subunit+16S RRNA + tRNA fMet + mRNA + antibiotics
3uzl, 3uzm - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA + paromomycin

S15 in small ribosomal subunit + ribosome recycling factor

2qbd, 2qbf – EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor
3r8n, 3r8o, 4gd1, 4gd2 – EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA
2qbh, 2qbj - EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin
2v46, 2v48 - TtRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet

S15 in small ribosomal subunit + elongation factor (EF)

2wri, 2wrk - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G
2wrn, 2wrq - TtRPS15 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4
3fic - TtRPS15 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A
4abr - TtRPS15 in 30S ribosomal subunit+THX + E/P-site tRNA fMet +mRNA codon+16S RRNA+elongation factor TU
3izv – EcRPS15 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU
3j18 - EcRPS15 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+ mRNA + SSRA-binding protein + formyl-Met specific initiator tRNA + elongation factor G – Cryo-EM
3izw – EcRPS15 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU
2y0u, 2y0w, 2y0y, 2y10, 2y12, 2y14, 2y16, 2y18 - TtRPS15 in 30S subunit+THX+A-site tRNA+E-site tRMA+mRNA codon+16S RRNA+elongation factor TU
3fih - EcRPS15 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU
3huw, 3huy - TtRPS15 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P
4b8f, 4b8h - TtRPS15 in 30S ribosomal subunit+THX+RNA+mRNA +16S RRNA+EF-G
4btc, 4kdg, 4kdj - TtRPS15 in 30S ribosomal subunit+THX+RNA +16S RRNA+EF-G
4juw - TtRPS15 in 30S ribosomal subunit+THX+ tRNA Phe +16S RRNA + mRNA +EF-G
4kbt, 4kbv, 4kcy, 4kd0, 4kd8, 4kda - TtRPS15 in 30S ribosomal subunit+THX+ tRNA Met +16S RRNA + mRNA + viomycin + EF-G
4kiy, 4kj0, 4kj2, 4kj4, 4kj6, 4kj8, 4kja, 4kjc - EcRPS15 in 30S ribosomal subunit +16S RRNA + viomycin + EF-G

S15 in small ribosomal subunit + translation initiation factor

1i96 - TtRPS15 in 30S ribosomal subunit+THX+IF3+16S RRNA
1hr0 - TtRPS15 in 30S ribosomal subunit+THX+IF+16S RRNA

S15 in small ribosomal subunit + various proteins

3kiq, 3kis, 3kiu, 3kix - TtRPS15 in 30S ribosomal subunit+toxin RelE+16S RRNA
4dh9, 4dhb - TtRPS15 in 30S ribosomal subunit +16S RRNA+mRNA+P-site tRNA fMet +THX + YAEJ
1voq, 1vos, 1vov, 1vox, 1voz - EcRPS15 in 30S ribosomal subunit+protein Y+16S RRNA
3j36 - EcRPS15 in 30S ribosomal subunit+ tetracycline resistance protein +16S RRNA + mRNA + P-tRNA – Cryo-EM
2xfz, 2xg1 - TtRPS15 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA
3jyv - RPS15+RPS0+RPS2+RPS3+RPS5+RPS9+RPS11+RPS13+RPS14+RPS16+RPS18+RPS20+RPS22+RPS23+RPS29+18S RRNA+RACK1+S19E+tRNA – Cryo-EM - Thermomyces lanuginosus
3j00 – EcRPS15 in 30S ribosomal subunit + 16S RRNA + mRNA + FTSQ + apolipoprotein A-I – Cryo EM
2ykr – EcRPS15 + 16S RRNA + GMPPNP + GTPase RSGA
4adv - EcRPS15 + 16S RRNA + methyltransferase – Cryo EM
3v22, 3v24, 3v26, 3v28 – TtRPS12 in 30S ribosomal subunit +16S RRNA +THX + modulation factor
3v2c, 3v2e – TtRPS15 in 30S ribosomal subunit +16S RRNA +THX + ribosome-associated inhibitor
3iz6 - RPS15 in 40S ribosomal subunit+RACK1 – wheat – Cryo EM
4a2i – EcRPS15 + 16S RRNA + GTPase RSGA – Cryo EM

S15 in small 40S ribosomal subunit + various proteins

3iz6 - RPS15 in 40S ribosomal subunit +RACK1+18S RRNA – wheat – Cryo-EM
3izb - yRPS15 in 40S ribosomal subunit+ RACK1 – yeast - Cryo-EM
3u5c, 3u5g - yRPS15 in 40S ribosomal subunit+ RACK1 + suppressor protein SMT1
3o2z, 3o30 - yRPS15 in 40S ribosomal subunit +RACK1
1s1h - yRPS15 in 40S ribosomal subunit+18S RRNA+EF-2 – Cryo-EM
3j38 - RPS15 in 40S ribosomal subunit + EF-2 + guanine nucleotide-binding protein – Drosophila melanogaster – Cryo-EM
3j3a - RPS15 in 40S ribosomal subunit + EF-2 + guanine nucleotide-binding protein – human – Cryo-EM
4kzx - rRPS15 in 40S ribosomal subunit+ RACK1 + EIF1 – rabbit – Cryo-EM
4kzy - rRPS15 in 40S ribosomal subunit+ RACK1 + EIF1 + EIF1A – Cryo-EM
4kzz - rRPS15 in 40S ribosomal subunit+ RACK1 + EIF1A + initiator tRNA – Cryo-EM

S15 in part of small ribosomal subunit

3iy8 - EcRPS15+EcRPS5+EcRPS6+EcRPS9+EcRPS9 EcRPS8+EcRPS11+EcRPS12+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA
1g1x - TtRPS15+TtRPS6+TtRPS18+16S RRNA fragment
1qd7 – TtRPS15+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS6+TtRPS17+TtRPS20+16S RRNA fragment

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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