Structural highlights
4py0 is a 1 chain structure. Full crystallographic information is available from OCA.
Related: 4ntj, 4pxz
Activity: Glucokinase, with EC number 2.7.1.2
Disease
[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
Function
[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
References
