2lzp

From Proteopedia

Revision as of 06:35, 9 April 2014 by OCA (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 2lzp

Contents

Structure of NS2(2-32) GBVB protein

Function

[POLG_GBVB] Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Probably also regulates many host cellular functions such as antiviral state inhibition, cell transformation and apoptosis (By similarity).[1] Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane (By similarity).[2] P13 may function as a multimeric ion channel protein (viroporin).[3] Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3 (By similarity).[4] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B (By similarity). NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the human antiviral protein MAVS.[5] NS5A is a component of the replication complex involved in RNA-binding (By similarity).[6] NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication (By similarity).[7]

About this Structure

2lzp is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103
  2. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103
  3. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103
  4. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103
  5. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103
  6. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103
  7. ↑ Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21. PMID:16492760 doi:http://dx.doi.org/0511297103

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lzp"
Personal tools