4msx

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Template:STRUCTURE 4msx

Contents

Crystal structure of an essential yeast splicing factor

Template:ABSTRACT PUBMED 24681967

Function

[SAD1_YEAST] Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle. Required for splicing of pre-mRNA.[1]

About this Structure

4msx is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Hadjivassiliou H, Rosenberg OS, Guthrie C. The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. RNA. 2014 Mar 28. PMID:24681967 doi:http://dx.doi.org/10.1261/rna.042838.113
  1. ↑ Lygerou Z, Christophides G, Seraphin B. A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. Mol Cell Biol. 1999 Mar;19(3):2008-20. PMID:10022888

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