4bbx

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Template:STRUCTURE 4bbx

Contents 1 Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia 2 Function 3 About this Structure 4 Reference

Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia

Function

[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.^[1]

About this Structure

4bbx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385