2me4
From Proteopedia
Contents |
HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle
Template:ABSTRACT PUBMED 24075869
Function
[Q27Q69_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
About this Structure
2me4 is a 1 chain structure with sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA.
Reference
- Sun ZY, Cheng Y, Kim M, Song L, Choi J, Kudahl UJ, Brusic V, Chowdhury B, Yu L, Seaman MS, Bellot G, Shih WM, Wagner G, Reinherz EL. Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41. J Mol Biol. 2013 Sep 26. pii: S0022-2836(13)00614-1. doi:, 10.1016/j.jmb.2013.09.030. PMID:24075869 doi:http://dx.doi.org/10.1016/j.jmb.2013.09.030
