3sfk
From Proteopedia
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267
Template:ABSTRACT PUBMED 21696174
About this Structure
3sfk is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
Reference
- Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford D, Barturen I, Ferrer S, Jimenez-Diaz MB, Gamo FJ, Goldsmith EJ, Charman B, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Jun 22. PMID:21696174 doi:10.1021/jm200592f
Categories: Dihydroorotate dehydrogenase | Plasmodium falciparum 3d7 | Deng, X. | Phillips, M. | Alpha beta barrel oxidoreductase | Alpha beta fold | Flavoprotein | Fmn | Inhibitor dsm267 | Mitochondrion inner membrane | Oxidoreductase-oxidoreductase inhibitor complex | Plasmodium falciparum membrane mitochondrion | Pyrimidine biosynthesis
