4emv

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Image:4emv.jpg

Template:STRUCTURE 4emv

Crystal structure of a topoisomerase ATP inhibitor

Template:ABSTRACT PUBMED 22814212

About this Structure

4emv is a 1 chain structure with sequence from Streptococcus pneumoniae ga47373. Full crystallographic information is available from OCA.

Reference

  • Manchester JI, Dussault DD, Rose JA, Boriack-Sjodin PA, Uria-Nickelsen M, Ioannidis G, Bist S, Fleming P, Hull KG. Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5150-6. Epub 2012 Jun 19. PMID:22814212 doi:10.1016/j.bmcl.2012.05.128

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OCA

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