Intercellular adhesion molecule

Function

Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to LFA-1 and macrophage-1 antigen during inflammation. ICAM contains 5 Ig-like domains.

Disease

Relevance

Structural highlights

3D structures of intercellular adhesion molecule

Updated on 06-July-2014

ICAM-1 (CD54)

1iam, 1ic1, 1d3l – hICAM N terminal domain – human
1p53 – hICAM domain 3-5

ICAM-1 complexes

1d3e, 1d3i – hICAM N terminal domain + rhinovirus coat proteins - CryoEM

1mq8 – hICAM domain 1-2 + LFA-1
3tcx – hICAM domain 1 + LFA-1
1z7z – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM
2qz4 – hICAM domain 4 + antibody

ICAM-2

1zxq – hICAM extracellular domain

ICAM-3

1t0p – hICAM N terminal domain + LFA-1

ICAM-5

3bn3 – hICAM N terminal domain + LFA-1

References