4kr9

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Template:STRUCTURE 4kr9

Contents

Crystal structure of a 4-thiouridine synthetase - RNA complex at 3.5 Angstrom resolution

Template:ABSTRACT PUBMED 24705700

Function

[THII_THEMA] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).

About this Structure

4kr9 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Neumann P, Lakomek K, Naumann PT, Erwin WM, Lauhon CT, Ficner R. Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification. Nucleic Acids Res. 2014 Apr 5. PMID:24705700 doi:http://dx.doi.org/10.1093/nar/gku249

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