Function
MEP cytidylyltransferase (MEPCT) catalyzes the conversion of 2C-methyl-D-erythritol 4-phosphate and CTP to 4-(cytidine 5’-diphospho)- 2C-methyl-D-erythritol (CDP-ME) and diphosphate. MEPCT participates in isoprenoid biosynthesis in many bacteria while eukaryotes use the mevalonic acid pathway for the isoprenoed biosynthesis
Disease
Relevance
Inhibitors of MEPCT can be used as potential antibiotics.
Structural highlights
3D structures of MEP cytidylyltransferase
Updated on 22-July-2014
1inj, 1vgt, 3n9w – EcMEPCT – Escherichia coli
1h3m – EcMEPCT (mutant)
1vgw, 1vgz – MEPCT – Neisseria gonorrhoeae
2px7 – MEPCT - Thermus thermophilus
2vsh – SpMEPCT - Streptococcus pneumoniae
4kt7 – MEPCT – Anaerococcus prevotii
4myb – MEPCT – Francisella tularensis
4nai – AtMEPCT CT domain – Arabidopsis thaliana
MEP cytidylyltransferase complex with cytidine
1i52 – EcMEPCT + CTP
1ini – EcMEPCT + CDP-ME
1vpa – MEPCT + CTP – Thermotoga maritima
1w77 – AtMEPCT CT domain (mutant) + CMP
2xwl – MsMEPCT + CTP – Mycobacterium smegmatis
2xwm – MsMEPCT + CMP
2xwn, 3q7u – MtMEPCT + CTP - Mycobacterium tuberculosis
3q80 – MtMEPCT + CDP-ME
MEP cytidylyltransferase other complexes
2wc3, 2wc5, 2ycm – AtMEPCT CT domain + herbicide
3okr – MtMEPCT + peptide
4nak, 4nal, 4nan – AtMEPCT CT domain (mutant) + pseudilin derivative
2vsi – SpMEPCT + pyrimidine derivative
References
