MurD ligase or UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase catalyzes the conversion of UDP-N-acetylmuramoyl-L-alanine (UMA), D-glutamate and ATP to UDP-N-acetylmuramoyl-L-alanine-D-glutamate and ADP. MurD is part of the bacterial peptidoglycan synthesis pathway.
3D Structures of MurD ligase
Updated on 30-March-2014
1e0d – EcMurD – Escherichia coli
3lk7 – MurD – Streptococcus agalactiae
4bub – TmMurD – Thermotoga maritima
MurD complex with ligand
1uag, 1eeh – EcMurD + UMA
2jfg – EcMurD + UMA + ADP
2uag – EcMurD + UMA + ADP + Mg
3uag – EcMurD + UMA + ADP + Mn
4uag – EcMurD + UAG
4bub – TmMurD + ADP
MurD complex with inhibitor
2jff, 2jfh, 2uuo, 2uup, 2vtd, 2vte, 2xpc – EcMurD + sulfonamide inhibitor
2wjp – EcMurD + rhodanine inhibitor
2x5o, 2y68, 2y66, 2y67, 2y1o – EcMurD + thiazolidine inhibitor
