1d2m
From Proteopedia
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UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME
Overview
In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed.
About this Structure
1D2M is a Single protein structure of sequence from Thermus thermophilus with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:10578047
Page seeded by OCA on Thu Feb 21 12:12:21 2008
Categories: Single protein | Thermus thermophilus | Fukuyama, K. | Kato, R. | Kuramitsu, S. | Masui, R. | Nakagawa, N. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Sugahara, M. | BOG | SO4 | Multidomain protein | Riken structural genomics/proteomics initiative | Rsgi | Structural genomics
