1d5v
From Proteopedia
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SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)
Contents |
Overview
Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.
Disease
Known diseases associated with this structure: Lymphedema and ptosis OMIM:[602402], Lymphedema, hereditary II OMIM:[602402], Lymphedema-distichiasis syndrome OMIM:[602402], Lymphedema-distichiasis syndrome with renal disease and diabetes mellitus OMIM:[602402], Yellow nail syndrome OMIM:[602402]
About this Structure
1D5V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11., van Dongen MJ, Cederberg A, Carlsson P, Enerback S, Wikstrom M, J Mol Biol. 2000 Feb 18;296(2):351-9. PMID:10669593
Page seeded by OCA on Thu Feb 21 12:13:15 2008
